What To Know About The Precede Consortium

April 10, 2023
Precede Foundation

The Pancreatic Cancer Early Detection (PRECEDE) Consortium is an international, multi-institutional collaborative group of experts that was established several years ago to increase survival for pancreatic cancer patients. Its mission is to increase the 5-year survival rate from 12% to 50% by improving early detection and screening for those at elevated risk of developing pancreatic cancer.

Pancreatic cancer has the highest mortality rate of all major cancers. It is currently the 3rd leading cause of cancer-related death in the United States after lung and colon and is projected to become the 2nd cause of cancer deaths by 2030. Both the incidence and the mortality figures are still steadily rising!

Sadly, pancreatic cancer still has one of the lowest 5-year survival rates of any kind of cancer, at about 12%. It’s time to dramatically increase that number.

Cancer survival rates are often measured in 5-year increments, meaning that percentage represents people who survive 5 years after their diagnosis. The good news is that the risk of cancer recurrence generally decreases over time, but it’s still different for each disease and patient.

What does the Precede Consortium do?

The Precede Consortium works collaboratively with its members and partners to advance its mission. The Precede Consortium is currently involved in several projects aimed at increasing the 5-year survival rate from 12% to 50% within the next 10 years.

TrovaNOW is raising funds for PRECEDE – an international, multi-institutional collaborative consortium of world-renowned experts in pancreatic cancer.

With over 30 leading academic medical centers across the globe, PRECEDE has assembled the largest high-risk patient cohort, with longitudinal clinical data and biospecimen acquisition and tracking.

How will we do this? Transform these rates with research, early detection, and prevention strategies for pancreatic cancer.

Pancreatic cancer survivor Jamie Brickell shares how early detection of pancreatic cancer saved his life. We are thrilled to have him currently serving on our Board of Directors!

Early detection is the biggest opportunity to address this disease. We are establishing a first-of-its-kind program for early detection and prevention. This includes a research initiative to identify biomarkers of abnormal pancreatic cells so we can intervene before they become invasive cancer cells. We’re also focusing on people who have had multiple family members with pancreatic cancer or who have mutations linked to pancreatic cancer. The goal is to develop new treatment paradigms to markedly delay or prevent the formation of pancreatic cancer in high-risk individuals.

We are proud to stand together at the edge of making a dent in pancreatic cancer and moving towards a brighter, healthier, more vibrant future. TrovaNow’s own Chief Scientific Advisor, Dr. Diane M. Simeone, MD shares more:

“Patients are counting on us to do something about this disease, it is going to be a big job. It is not just our academic institutions that are going to make this happen. This year is going to be our break-out year, so everybody get ready for the ride!”

How To Donate To Cancer Research?

This is our chance to shine a light on this misunderstood disease by coming together as a community to raise awareness. With your support and funding, we can improve research and early detection mechanisms – our greatest chance to improve survival rates.

Learn how you can be part of the revolutionary mission to increase survival rates for pancreatic cancer patients around the globe. Visit www.trovanow.org to learn how you can get involved and donate today. 

Knowing When To Ask For Help

There’s strength in recognizing when you need additional support. If you’re feeling consistently overwhelmed, anxious, or depressed, it may be time to speak with a healthcare professional. Warning signs can include ongoing sleep trouble, loss of appetite, or emotional numbness.

Mental health care is an important part of cancer recovery. There are therapists, social workers, and cancer-specific counselors trained to support your unique needs. Don’t hesitate to seek them out.

Your medical team can help adjust medications or recommend physical therapy if your symptoms are impacting your daily life. Being honest about your struggles allows your care providers to offer better, more personalized support.

The path to recovery from pancreatic cancer is rarely straightforward. It’s a mix of triumphs and setbacks, strength and vulnerability. But through each high and low, healing is happening. Be gentle with yourself. Allow space for rest, reflection, and growth.

You don’t have to go through this journey alone. With the right support, emotional, physical, and practical, you can move forward, one step at a time. And remember, every day you show up for yourself is a victory.

At TrovaNOW, we’re focused on finding a cure for pancreatic cancer. Every test and discovery brings us closer to better treatments and saving lives. Join us and learn more at TrovaNOW.

Jaundice: A Vital Early Warning Sign for Pancreatic Cancer — Insights from Diane Simeone, MD

We are pleased to share that Dr. Diane Simeone, Chief Scientific Advisor to the Precede Foundation and founding director of the PRECEDE consortium, was recently spotlighted in a New York Post article published on August 5, 2025. In the feature, Dr. Simeone underscores how jaundice—yellowing of the skin and eyes—is one of the most telling early signs of pancreatic cancer, a disease notorious for its subtle onset and low five‑year survival rate. Below, you’ll find a curated excerpt capturing her insights; or click here to read the full article for additional context and details.

Pancreatic cancer remains one of the most lethal cancers, with only about a 13 percent five‑year survival rate, largely due to its frequently silent early stage. In a recent New York Post article published on August 5, 2025, Dr. Diane Simeone—Chief Scientific Advisor and founding director of the Pancreatic Cancer Early Detection Consortium (PRECEDE)—emphasizes that jaundice, marked by yellowing of the skin or eyes, is among the most distinctive and potentially life-saving early indicators of pancreatic cancer.

Because tumors often develop deep within the pancreas, symptoms such as fatigue, unexplained weight loss, or digestive discomfort are typically vague and easily misattributed. Jaundice more reliably points toward a tumor obstructing the bile ducts, leading to bilirubin buildup. Additional red flags include dark urine, pale stools, itchy skin, and abdominal discomfort.

Dr. Simeone also highlights PRECEDE’s mission: to elevate the five‑year survival rate from 13 percent to 50 percent by standardizing early screening protocols, validating biomarkers, and accelerating the development of early detection tools—potentially including a blood‑based test.

PRECEDE Foundation Inaugural Gala

Join us for a night at the Tribeca Rooftop 360 on October 28th at 3:00pm PDT to honor the following awards:

Nobility in Science Award

Raymond C. Wadlow, MD

Catalyst for Change Award

Ambry Genetics Corporation

Legacy Awards

Jeffrey Johnson, Esq.

Jonathan Morris, Esq.

Voices for a Cure Award

Jay Canell

Neil Canell

PRECEDE Leadership and Compassionate Care Award

Jessica Everett, MS, CGC

Co-Chairs

Scott Berger | Michael Gershenson | Tracy Chen

Honorary Chairs

Diane Simeone, MD | Jamie Brickell

Host Committee

Kiran Kalsi Chapman
Barbara Grenell
Sony Kalsi
Scott Litman
Joshua Raff, MD
Randi Seidner
Sheri & Craig Tendler

Get tickets here.

A Long and Steadfast Battle Against a Terrible Cancer

Raymond Wadlow lost his mom, Emily Couric, to pancreatic cancer in 2001. Today he’s an oncologist pushing for early detection.